Nature Methods has declared Single-cell sequencing its Method of the Year for 2013, which obviously I think is a great choice. The January 2014 issue comes with news features by Tal Nawy and Kelly Rae Chi, and reviews by Paul Blainey and Steve Quake on single-cell genomics, good friend Rickard Sandberg on single-cell transcriptomics, and James Eberwine and colleagues on multimodal single-cell measurement technologies.