Cell types of the cortex and hippocampus revealed by single-cell RNA-seq (paper)

We applied single-cell analysis to the mouse cortex and hippocampus - to our knowledge the most complex tissues analyzed in this way by single-cell methods. We describe 47 distinct subclasses of cells, and find that transcription factors form a complex, layered regulatory code.

This work was a very rewarding collaboration primarily with the Jens Hjerling-Leffler group, as well as a large team of collaborators. I think it proves, once and for all, that single-cell gene expression analysis will revolutionize developmental biology. With single-cell analysis, we have an objective way of observing and classifying all the cells that exist in any tissue, at any time.

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq Published in Science (PDF) (Companion data)

Press reports

“Detailed map of the brain reveals SEVEN unknown types of cells” Daily Mail

“Single-cell RNA-seq IDs Dozens of Mammalian Brain Cell Subtypes” GenomeWeb

“New brain mapping reveals unknown cell types” MedicalXPress

“Elaborata nuova mappa del cervello: stanate cellule sconosciute” MeteoWeb

“Nya hjärnceller upptäckta” Uppsala Nya Tidning

“Ny kartläggning avslöjar okända celltyper” Karolinska Institutet

“Kartläggning av hjärnan avslöjar okända celltyper” Forskning.se

“Nya hjärnceller hittade av svenska forskare” Dagens Nyheter