In a study led by Hannah Hochgerner and Amit Zeisel, we use scRNA-seq to explore hippocampal neurogenesis across ages, from embryonic to adult. We show that the neurogenic program follows a highly conserved trajectory, but with significant transformations of key cell types at specific timepoints: radial glia around the second postnatal week, and granule cells around week three.
Conserved properties of dentate gyrus neurogenesis across postnatal development revealed by single-cell RNA sequencing.
Published in Nature Neuroscience
See also the News & Views piece by Ben Dulken and Anne Brunet, Same path, different beginnings.